Author Topic: Hack my Blood Work  (Read 4552 times)

Offline cowlean

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Hack my Blood Work
« on: July 09, 2016, 04:07:29 AM »
Hi Guys,

Recently got my blood work back from the doctor. He's advising (in particular) high total cholesterol, including high HDL and LDL, and high uric acid. I'd love to know what are the takeaways from these results, what I could change, and what should stay the same!

I want to feel great, rather than just average, so please point out anywhere I can improve! :D

FYI I'm a 23 year old male, living in the UK. I eat Paleo and non-dairy except for very dark chocolate and grass fed butter. I buy grass fed, organic and wild caught meat, fish and veg wherever possible.

Apologies for the formatting of the results. There are a few blank pages to begin.... I haven't worked out a way via Chromebook to efficiently edit PDFs!

Offline Warren Dew

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Re: Hack my Blood Work
« Reply #1 on: July 09, 2016, 11:12:22 AM »
I wouldn't worry about the total cholesterol.  You're at about 220 mg/dl, which is in fact the perfect place to minimize total cause mortality; see this graph:

http://perfecthealthdiet.com/wp/wp-content/uploads/2011/06/O-Primitivo-Cholesterol.jpg

Recommendations to keep cholesterol below 200mg/dl are based on minimizing ischemic heart disease, and ignoring the concomitant increases in hemorrhagic stroke and communicable diseases.

While HDL (good cholesterol) is already in a good range, you could possibly increase it a bit more with more exercise.  The LDL levels in your tests are calculated using a formula that is incorrect given your low levels of triglycerides; in fact you are most likely fine on LDL and by normal standards your triglycerides are exceptionally good.  There's a post on this forum somewhere on the details of that calculation.  Incidentally the low triglycerides are one effect of paleo being a low carb diet by normal standards.

The uric acid is likely because your body is using it as a reducing agent ("antioxidant") to compensate for lack of dietary vitamin C.  You could possibly eat more fruit high in vitamin C, like lemons, strawberries, and kiwi fruit, or take a vitamin C supplement of a couple of grams per day; that might  also make you feel slightly better.  Excessive levels of uric acid are associated with gout but I don't think you're really that high.

Being in ketosis, if you aren't already, might make you feel a bit better, but keep in mind that "average" for a 23 year old is "great" for a 50 year old.  However, some high intensity interval training, if you aren't already doing it, can increase your aerobic rate and would likely make you feel even better.

Your vitamin D levels, while in the normal range, are a bit low; given you are in the UK, sunlight might be hard to come by, but a vitamin D3 supplement might be good if you aren't already taking one.  This can help with mood and likely helps prevent cancer.


Offline cowlean

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Re: Hack my Blood Work
« Reply #2 on: July 10, 2016, 02:32:47 AM »
Hi Warren,

Thanks for info. I already have Vit C powder so I'll make sure I'm getting a couple of grams every day now. Before, I was having it now and then.

How does the body utilise the C to "antioxidise"?

I play football once a week and lift weights twice a week. Would you recommend more then?

I'll look for a Vit D supplement today. Is D3 different to D(any other number)?

Offline Warren Dew

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Re: Hack my Blood Work
« Reply #3 on: July 10, 2016, 10:33:41 PM »
As you probably know, proteins are made up of amino acids coded for by DNA.  However, for certain connective tissue proteins to work properly, some of their amino acids must be reduced to a different form after the protein is constructed.  Vitamin C acts as a reducing agent to do that.  ("Reduce" is the chemical opposite of "oxidize".)

In addition, it appears that Vitamin C is needed for proper white blood cell function.

More exercise is usually better, but to be honest, what you are doing now is probably fine.

Some sources say D3 is preferred to other forms of vitamin D, and other sources say it makes no difference.  Nothing says the other forms are better, so I play it safe and use D3.  I'd recommend between 2000 and 4000 IU per day; 2000 is comfortably above the 1100 IU per day that has been shown to help prevent cancer in at least some population groups.


Offline cowlean

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Re: Hack my Blood Work
« Reply #4 on: July 12, 2016, 01:30:17 PM »
I've picked up my D supplement and took 2 on Sunday and Monday, and 3 today. What are your opinions on Asprey's recommendation: 1000IU per 25 lbs of body weight? For me that means working up to 8000IU. A little internet research shows we create up to 10000IU safely from the sun so doing so would be fine?

Currently I'm having roughly 2.5g of C as well, in the morning.

By increasing the doses of both what should I look out for specifically?


Offline Warren Dew

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Re: Hack my Blood Work
« Reply #5 on: July 13, 2016, 01:54:36 AM »
For vitamin D, I think 1000IU per 25 pounds is probably toward the high end of the reasonable band.  Personally I'm about 140 pounds and target 4000IU per day.  I say "target" because some days I forget, and other days I'm sure I forget I took them and take them again.  It's easy for me to forget because I try to take vitamin D with fatty foods, which improves absorption, but I don't always eat at regular times.

If you are already getting 2.5g of vitamin C in the morning, I'd suggest adding some in the evening rather than increasing the morning dose, as vitamin C has a fairly short biological half life.

For vitamin D, I first experimented with a single 5000 IU dose initially, and it made me itchy in multiple locations for a day or two.  Once I started taking 2000IU/day regularly, a 5000 IU dose no longer did this.  I now believe that the itchiness had to do with sudden destruction of most of a relatively high population of precancerous cells; of course you are younger so you probably have a much lower population of precancerous cells at present.

If you start seeing symptoms of vitamin D toxicity, you might reduce the dose.

For vitamin C, you might see if your pulse seems stronger, one indication of blood vessel elasticity.  If you have gout you might see the symptoms abate, though I presume you don't have it.

Offline cowlean

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Re: Hack my Blood Work
« Reply #6 on: July 13, 2016, 11:32:57 PM »
Nope no gout :)

What are the symptoms of Vitamin D toxicity?

Offline Warren Dew

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Re: Hack my Blood Work
« Reply #7 on: July 14, 2016, 04:13:29 AM »
There's a reasonable discussion here:

http://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/expert-answers/vitamin-d-toxicity/faq-20058108

Basically, you get too much calcium in the bloodstream, which has a variety of consequences.

Come to think of it, I've been having occasional minor kidney discomfort and possible small kidney stones, so maybe I should cut back a bit.  I'll try targeting 2000 IU per day for a while.

Offline cowlean

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Re: Hack my Blood Work
« Reply #8 on: July 14, 2016, 01:53:30 PM »
That article said roughly 50000 IU would be required for toxicity though? Sounds pretty reasonable that I won't get to that level ;)

So the report also showed high lymphocytes. Is this immune system related or more due to high fat consumption (lymphatic system)?

Offline Warren Dew

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Re: Hack my Blood Work
« Reply #9 on: July 15, 2016, 04:04:20 PM »
I'm sure my symptoms don't rise to the level of clinical toxicity.  I'd still rather not have even slightly achy kidneys when I wake up.  2000 IU should be plenty to get most of the cancer prevention benefit, so there's a wide range to work with.  I'll report back in a few weeks.

Lymphocytes are immune system related - white blood cells - and I suspect the vitamin C might help there as well as with the uric acid.

Offline cowlean

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Re: Hack my Blood Work
« Reply #10 on: July 17, 2016, 01:59:06 AM »
Okay, that's interesting. How come lymphocytes and the lymphatic system aren't related?

I'm currently having 2.5g of C in the morning and the evening, and I certainly haven't hit bowel intolerance yet. Should I up the dosage?

Offline Warren Dew

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Re: Hack my Blood Work
« Reply #11 on: July 17, 2016, 06:30:06 AM »
Lymphocytes and the lymphatic system are related; sorry if I seemed to imply otherwise.  The lymphatic system is a way for lymphocytes to aggregate where they are needed.  This is why lymph nodes swell when we get sick.

I wouldn't necessarily further increase the dosage of vitamin C until after seeing a follow up blood test.

Offline cowlean

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Re: Hack my Blood Work
« Reply #12 on: July 17, 2016, 07:26:16 AM »
Does that imply then that we need to consume fats to work out lymphatic system? (bit of bro science theorising going on here...)

Hmmm, good point.

What's your opinion on magnesium supplementation?

Offline Warren Dew

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Re: Hack my Blood Work
« Reply #13 on: August 04, 2016, 10:11:18 AM »
I'm sure my symptoms don't rise to the level of clinical toxicity.  I'd still rather not have even slightly achy kidneys when I wake up.  2000 IU should be plenty to get most of the cancer prevention benefit, so there's a wide range to work with.  I'll report back in a few weeks.
Things have been much better.  On the other hand, I've also been careful not to use my arms as a pillow, so the reduction in bone pain after sleeping on them may be due to that instead.  I'll probably continue targeting 2000 IU per day instead of 4000, erring on the high side if I can't remember whether I took it.