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Research / Placebo-controlled study shows that non-celiac gluten sensitivity exists
« Last post by Eric on February 28, 2015, 08:23:47 AM »
Small Amounts of Gluten in Subjects with Suspected Nonceliac Gluten Sensitivity: a Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial.


In a cross-over trial of subjects with suspected NCGS, the severity of overall symptoms increased significantly during 1 week of intake of small amounts of gluten, compared with placebo. Clinical trial no: ISRCTN72857280.
Diet and nutrition / Eating Paleo/Vegetarian and left feeling like I need something
« Last post by Tessa on February 27, 2015, 06:00:53 PM »
This might be hard to express, but I have been eating Paleo for 3 months, lost a significant amount of weight, had a plateau and decided to eat more veges and less meat. Started losing again, I am consuming alot of calories a day, and a alot of food, I feel full, happy and healthy but I also feel like I need something solid to eat, nothing seems to hit the spot. I feel like I eat alot of watery based foods and my body is craving something. I hate to say carby because I wont eat toast or pasta, but I think I might kill for a cracker. I cant seem to find a paleo one thats satisfying. Does anyone relate, have any suggestions? Will this at least pass?
Diet and nutrition / Re: Seeds and nuts question
« Last post by Tessa on February 27, 2015, 05:52:42 PM »
They are a good natural source of vitamins, minerals, protein, fat, fiber and so I try to eat nuts and seeds every day, only thing is that they tend to be bit pricey...

What ones do you eat everyday? I read so much about them but unsure which ones should be daily or just every so often, how much, etc
Diet and nutrition / Paleo Diet!?
« Last post by Paleo124 on February 22, 2015, 03:23:36 PM »
Free for today: Everyday Paleo Recipes in a Mason Jar! Hey friends, this book is free on Kindle for Today. if you don't have a kindle you can use their free cloud reader app. Check it out:
Exercises / Re: Can't keep food down after a work out- suggestions?
« Last post by Cait1221 on February 22, 2015, 12:41:56 PM »
Gall bladder******
I really should reread things before posting them.
Exercises / Re: Can't keep food down after a work out- suggestions?
« Last post by Cait1221 on February 22, 2015, 12:40:13 PM »
I've tried talking to doctors, and I wound up actually having to leave my old general practitioner because he told me I must be diabetic because my father had diabetes and then tried to send me to a surgeon to have my fall bladder removed with normal ball bladder scans and tests. (Even though all my blood tests for blood sugar came back PERFECT- and he checked every couple weeks...). I've given up on doctors advice since its getting me no where.
I've never thought of being too low on salt. I do eat on an overall low sodium diet just because I don't like salty things. I honestly don't really know what I eat before runs and working out. It's usually just whatever is available for me to eat quickly. I'll have to start paying attention to that.
Research / Fatty acid mutation in coastal Inuit
« Last post by Warren Dew on February 22, 2015, 09:59:50 AM »
Apparently there's a kerfluffle between various ancestral health diet blogs about a mutation found in most coastal Inuit and almost no one else, and what its implications are regarding whether the Inuit were in ketosis most of the time, and whether they are a good model for the effects of long term ketosis in people without the mutation.  The information is sufficiently interesting that I thought I'd post a summary here.

The mutation is in the CPT1 gene, which is ultimately responsible for oxidation of long chain fatty acids.  The associated enzyme activity was reduced by a factor of roughly 17 in people homozygous for the mutation - that is, that had the mutation on both strands of their DNA - and appears to inhibit ketosis on modern diets.  Out of 422 consecutive infants screened from one affected region, 70% were homozygous for the mutation and another 24% were heterozygous - had the mutation on one of their two DNA strands.  A significant proportion of the affected people are in hypoketotic hypoglycemia - that is, have low blood sugar, but without the normal response of going into ketosis - and there were at least 10 infant deaths out of the 422 screened.

So basically we have a mutation that seems to kill a noticeable percentage of infants, but which has actually been selected for, rather than against, in coastal arctic Inuit populations.  The question is, why?

Petro Dobromylskyj, who writes the Hyperlipid blog, has an explanation that hangs together pretty well.  He notes that the coastal inuit's precontact diet was extremely high in fat and had virtually no carbohydrate.  He argues that with such a diet, the free fatty acid concentration in the body would increase to the point where even the small residual activity from the enzyme from the mutated CPT1 gene would be sufficient to allow adequate levels of long chain fatty acid metabolism.  This would explain why the mutation didn't get rapidly selected out of the gene pool, for this population.

There remains the question of why there was selection in favor of the mutation.  Dobromylskyj notes that normally, when the energy from oxidative metabolism is no longer needed, the enzyme from the CPT1 gene is inhibited by malonyl-COA.  The enzyme from the mutated CPT1 gene is not inhibited by malonyl-COA, so long chain fatty acid oxidation would continue even when the energy was not needed for normal functions:  the energy would simply be dissipated as heat when it wasn't powering muscles or other tissue activity.  In addition, the increased free fatty acid concentration would mean that this elevated level of metabolism could be sustained for much longer than in people without the mutation.  In the arctic areas where the mutation is found, the extra body heat would be adaptive:  for example, it could keep you alive through a cold night or rest period where normal humans would die of hypothermia.

What does this mean for the paleo diet, and for the argument that the Inuit are a model for a sustained ketogenic diet?  Well, it does mean that they metabolized an extremely high fat, virtually zero carb diet slightly differently from most of us.  The differences mean that such a high fat diet won't give most of us quite the ability to survive the arctic wilderness that it gave the Inuit.  On the other hand, the extra free fatty acid metabolism that the Inuit have on such a diet would mean that they would see a bit more oxidative stress than most of us on such a diet.

Ultimately, though, they were still likely in long term ketosis.  And, if anything, a long term ketogenic diet, outside of the arctic wilderness, is likely more healthy for us than for the Inuit, given our lower levels of oxidative stress on such a diet.
Miscellaneous / Re: Free images...?
« Last post by billyon on February 22, 2015, 09:23:00 AM »
Ok, cool, thanks!
Recipes and meal photos / Re: Some free recipes for you!
« Last post by iBlairr on February 20, 2015, 07:42:52 AM »
Hey! For some reason i must have forgot to add the link, that was a bit stupid of me haha!

Here's the link if you want to check them out:

Also i'll PM you and we can sort something out!

Recipes and meal photos / Re: Banoffee Pie Cheesecake? Oh yeah.
« Last post by iBlairr on February 20, 2015, 07:38:22 AM »
It's pretty simple ingrediants, blended cashews for the cheesecake mixed with banana, base is almond and top is coconut cream. Although the toffee is my favourite bit though, well tastey!

Here's the video like if you want to check it out!

And yeah unsettling is the right word haha, that was the first time i made it about a year ago when i was all instagram/filter crazy haha!

Let me know what you's think :)
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