Author Topic: Meta-analysis of animal fat or animal protein intake and colorectal cancer  (Read 1019 times)

Offline ajmesa

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I couldn't find a reference to this study in the forum and I think it will ease the worries of a few future new members:

http://www.ajcn.org/cgi/content/abstract/ajcn.2008.26838v1
Meta-analysis of animal fat or animal protein intake and colorectal cancer
Dominik D Alexander, Colleen A Cushing, Kimberly A Lowe, Bonnie Sceurman and Mark A Roberts
Am J Clin Nutr (March 4, 2009). doi:10.3945/ajcn.2008.26838

Quote
ABSTRACT

Background: In the recent World Cancer Research Fund/American Institute for Cancer Research report of diet and cancer, it was concluded that there is limited but suggestive evidence that animal fat intake increases the risk of colorectal cancer.

Objective: To clarify this potential relation, we conducted meta-analyses across a variety of subgroups, incorporating data from additional studies.

Design: Analyses of high compared with low animal fat intakes and categorical dose-response evaluations were conducted. Subgroup analyses, consisting of evaluations by study design, sex, and tumor site were also performed.

Results: Six prospective cohort studies with comprehensive dietary assessments, contributing 1070 cases of colorectal cancer and 1.5 million person-years of follow-up, were identified. The summary relative risk estimate (SRRE) for these studies was 1.04 (95% CI: 0.83, 1.31; P for heterogeneity = 0.221) on the basis of high compared with low intakes. When data from case-control studies were combined with the cohort data, the resulting SRRE was 1.15 (95% CI: 0.93, 1.42) with increased variability (P for heterogeneity = 0.015). In our dose-response analysis of the cohort studies, no association between a 20-g/d increment in animal fat intake and colorectal cancer was observed (SRRE: 1.02; 95% CI: 0.95, 1.09). In a separate analysis of 3 prospective cohort studies that reported data for animal protein or meat protein, no significant association with colorectal cancer was observed (SRRE: 0.90; 95% CI: 0.70, 1.15).

Conclusion: On the basis of the results of this quantitative assessment, the available epidemiologic evidence does not appear to support an independent association between animal fat intake or animal protein intake and colorectal cancer.
« Last Edit: March 25, 2010, 06:55:19 PM by ajmesa »
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