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Topics - Warren Dew

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Research / Ketones stabilize brain function
« on: May 21, 2020, 06:55:57 PM »
A couple of times recently, I've talked to smart people in my age range - I'm 60 - and they've remarked that they don't think they're as intelligent as they once were.  I have not noticed any degradation in myself.  This paper suggests that my switching to a ketogenic paleo diet a decade ago may be why.

"Large-scale life span neuroimaging datasets show functional communication between brain regions destabilizes with age, typically starting in the late 40s, and that destabilization correlates with poorer cognition and accelerates with insulin resistance. Targeted experiments show that this biomarker for brain aging is reliably modulated with consump- tion of different fuel sources: Glucose decreases, and ketones increase the stability of brain networks."

Miscellaneous / Paleo food prep in 30 seconds per day
« on: February 14, 2020, 06:16:30 PM »
Video showing daily food prep time of 30 seconds:

Fair warning:  she's meat only and eats one meal per day.

Miscellaneous / Queen Elizabeth doesn't like starches
« on: January 23, 2020, 01:33:49 PM »
"When she's on her own, then the Queen avoids most starches":

Miscellaneous / What did you have for Christmas dinner?
« on: December 26, 2019, 12:33:51 AM »
What did you have for Christmas dinner?

We had rib roast, USDA prime, and asparagus with melted butter.  Delicious!

Recipes and meal photos / Zhoukoudian soup
« on: January 04, 2018, 10:54:44 PM »
The lower Zhoukoudian cave was occupied by homo erectus around 700,000 years ago, and again by early modern humans in the late paleolithic, by which time the broad spectrum revolution had occurred and humans were likely using fruit, like the citrus found in Asia, and other vegetables to supplement their meat.  Spicy, sour soups like this one could have been made in leather pots using the heated rock method, but we'll use modern pots on the stove top.


1 quart bone broth (see recipe linked below)
4 oz pork or other meat
1/2 cup bamboo shoot
1/2 cup mushrooms
2 lemons
white pepper
1 egg
2 scallions

While heating the bone broth to a simmer in a saucepan, slice pork and bamboo shoots into strips, about 1/8 inch by 1/4 inch by 2 inches, and slice mushrooms 1/8 inch think.  Cut lemons in half and squeeze out the juice.  Finely grind 1/4 teaspoon white pepper.

Put pork, bamboo shoots, mushrooms, lemon juice, and ground pepper into heated bone broth.  Allow to simmer about 5 minutes stirring occasionally, while beating eggs in a bowl and chopping scallions into 1/4 inch pieces.

After the 5 minutes of simmering, pour eggs in a thin stream into the soup and stir.  Serve promptly with scallions on top of each serving.  Diners may wish to add more pepper to taste.

Serves 3-6.  Recipe may be doubled or quadrupled.

My other recipes:

Research / Dietary fat causes inverse effect on cholesterol
« on: July 26, 2017, 10:37:43 AM »
Article and, especially, video showing that total and LDL cholesterol levels vary inversely with the previous three day average dietary fat intake.

Research / Newly published Ancel Keys study
« on: April 28, 2017, 09:06:03 PM »
Hey, looky here!  Turns out our old friend Ancel Keys did a huge randomized controlled trial with a coworker on people in nursing homes and asylums trying to show that polyunsaturated fats would reduce heart attacks relative to saturated fats.  Then when the actual data showed there was no benefit - cholesterol was reduced, but as many or more people died - he never published the results.  But the truth got the last laugh, after he and a coworker died.

Miscellaneous / Is Hillary Clinton vegan?
« on: September 15, 2016, 10:42:53 PM »
Apparently one of the "drugs" Hillary Clinton's doctors say she takes is vitamin B12.

That makes me wonder if she's vegan.  Bill claims to be vegan but has salmon once a week.

If she's vegan, that could certainly explain her health problems.

Miscellaneous / I must be paleo if ...
« on: May 06, 2016, 02:14:42 PM »
... I run to the drugstore instead of walking because I'm in a hurry, rather than because I need the exercise.

Research / Modern hunter gatherers sleep less than 7 hours a night
« on: October 15, 2015, 08:30:38 PM »
While modern hunter gatherers may not accurately represent paleolithic humans, the fact that three widely separated groups all had the same sleep patterns, averaging 6.5 hours of sleep per night, suggests that this may be a natural amount of sleep.  They generally went to bed 3 hours after sunset and got up before dawn.  At least, that's what this study seems to have found.

Research / Calorie restriction extends lifespan in primates
« on: August 02, 2015, 07:11:57 PM »
Somehow I missed this when it came out.  Calorie restriction has previously been shown to extend lifespan in a wide variety of animals from microbes to rats.  Now that result has been extended to primates - specifically, rhesus monkeys.  A 30% calorie restriction resulted in about a 20% increase in lifetime when looking only at age related deaths, and about a 10% increase in lifetime when other causes of death were included.

Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice and rats. The value of CR as a tool to understand human ageing relies on translatability of CRs effects in primates. Here we show that CR significantly improves age-related and all-cause survival in monkeys on a long-term ~30% restricted diet since young adulthood.

Research / Paleolithic man consumed elephants in the levant
« on: April 05, 2015, 11:35:56 AM »
Data from a site in Israel show that during the paleolithic, humans skinned and processed hides from elephants.  Seems likely they were eating the meat and fat they were separating the hides from.

Research / Fatty acid mutation in coastal Inuit
« on: February 22, 2015, 09:59:50 AM »
Apparently there's a kerfluffle between various ancestral health diet blogs about a mutation found in most coastal Inuit and almost no one else, and what its implications are regarding whether the Inuit were in ketosis most of the time, and whether they are a good model for the effects of long term ketosis in people without the mutation.  The information is sufficiently interesting that I thought I'd post a summary here.

The mutation is in the CPT1 gene, which is ultimately responsible for oxidation of long chain fatty acids.  The associated enzyme activity was reduced by a factor of roughly 17 in people homozygous for the mutation - that is, that had the mutation on both strands of their DNA - and appears to inhibit ketosis on modern diets.  Out of 422 consecutive infants screened from one affected region, 70% were homozygous for the mutation and another 24% were heterozygous - had the mutation on one of their two DNA strands.  A significant proportion of the affected people are in hypoketotic hypoglycemia - that is, have low blood sugar, but without the normal response of going into ketosis - and there were at least 10 infant deaths out of the 422 screened.

So basically we have a mutation that seems to kill a noticeable percentage of infants, but which has actually been selected for, rather than against, in coastal arctic Inuit populations.  The question is, why?

Petro Dobromylskyj, who writes the Hyperlipid blog, has an explanation that hangs together pretty well.  He notes that the coastal inuit's precontact diet was extremely high in fat and had virtually no carbohydrate.  He argues that with such a diet, the free fatty acid concentration in the body would increase to the point where even the small residual activity from the enzyme from the mutated CPT1 gene would be sufficient to allow adequate levels of long chain fatty acid metabolism.  This would explain why the mutation didn't get rapidly selected out of the gene pool, for this population.

There remains the question of why there was selection in favor of the mutation.  Dobromylskyj notes that normally, when the energy from oxidative metabolism is no longer needed, the enzyme from the CPT1 gene is inhibited by malonyl-COA.  The enzyme from the mutated CPT1 gene is not inhibited by malonyl-COA, so long chain fatty acid oxidation would continue even when the energy was not needed for normal functions:  the energy would simply be dissipated as heat when it wasn't powering muscles or other tissue activity.  In addition, the increased free fatty acid concentration would mean that this elevated level of metabolism could be sustained for much longer than in people without the mutation.  In the arctic areas where the mutation is found, the extra body heat would be adaptive:  for example, it could keep you alive through a cold night or rest period where normal humans would die of hypothermia.

What does this mean for the paleo diet, and for the argument that the Inuit are a model for a sustained ketogenic diet?  Well, it does mean that they metabolized an extremely high fat, virtually zero carb diet slightly differently from most of us.  The differences mean that such a high fat diet won't give most of us quite the ability to survive the arctic wilderness that it gave the Inuit.  On the other hand, the extra free fatty acid metabolism that the Inuit have on such a diet would mean that they would see a bit more oxidative stress than most of us on such a diet.

Ultimately, though, they were still likely in long term ketosis.  And, if anything, a long term ketogenic diet, outside of the arctic wilderness, is likely more healthy for us than for the Inuit, given our lower levels of oxidative stress on such a diet.

Vitamins and Supplements / Eric - online vitamin source?
« on: December 04, 2014, 06:00:36 PM »
I need to order a bunch of vitamins for my kids.  Did you have a source that supports this site?

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