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Ketones stabilize brain function

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Warren Dew:
A couple of times recently, I've talked to smart people in my age range - I'm 60 - and they've remarked that they don't think they're as intelligent as they once were.  I have not noticed any degradation in myself.  This paper suggests that my switching to a ketogenic paleo diet a decade ago may be why.

"Large-scale life span neuroimaging datasets show functional communication between brain regions destabilizes with age, typically starting in the late 40s, and that destabilization correlates with poorer cognition and accelerates with insulin resistance. Targeted experiments show that this biomarker for brain aging is reliably modulated with consump- tion of different fuel sources: Glucose decreases, and ketones increase the stability of brain networks."

https://www.pnas.org/content/pnas/early/2020/03/02/1913042117.full.pdf

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